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Remember the original Zoloft commercial? The one where a sad little blob rolled around on screen with a rain cloud hovering over its head? That commercial first debuted back in 2001, and since then Zoloft, or Sertraline hydrochloride, has become one of the top psychiatric drugs used by American adults, according to one recent study. Zoloft is one of the first-line antidepressant medications prescribed for both depression and anxiety, meaning its one of the most likely to work, says Alison Hermann,.D., a clinical psychiatrist at Weill Cornell Medicine and New York-Presbyterian Hospital. Zoloft is part of a class of drugs called ssris, or selective-serotonin reuptake inhibitors. Their main effect has to do with changing the signaling of one of the main neurotransmitters in the brain, serotonin, which modulates mood, explains James Murrough,.D., the director of the Mood and Anxiety Disorders Program at the Icahn School of Medicine at Mount Sinai. These medicines tend to increase the availability of serotonin in the brain, which can help boost your mood. And thats the goal, right? In general, antidepressants are well tolerated. But, like with all drugs, there are Zoloft side effectssome of which are merely annoying and some of which can actually be dangerous. I generally start my patients on the lowest milligram pill and have them cut it in half for the few few doses just to make sure youre tolerating it before bumping it up, says Hermann. So if youre prescribed Zoloft, heres what to look out for. Zoloft is the brand name of sertraline, an antidepressant used to treat major depressive disorders. Zoloft is in a class of antidepressants known as selective serotonin reuptake inhibitors (ssris). They work by controlling levels of serotonin (a neurotransmitter) in the brain. Ssris are the most prescribed type of antidepressants in the United States today because they are thought to have fewer side effects than other types of antidepressants. Zoloft was originally developed for the United Kingdom market by Pfizer in 1990. It was released under the brand name Lustral and marketed as a safer alternative with fewer side effects and withdrawal symptoms than competing drugs like Prozac. The Food and Drug Administration (FDA) approved Zoloft in 1999. By 2005, it was reportedly the most popular antidepressant on the.S. Market and the sixth most prescribed brand-name prescription medication, grossing nearly.6 billion. In addition to treating major depressive disorders, which affect nearly 7 percent of adults in the United States, Zoloft is given to those suffering from post-traumatic stress disorder (ptsd), premenstrual dysphoric, and obsessive-compulsive disorder (OCD along with generalized anxiety disorder (GAD), and panic disorder. The generic form of Zoloft, sertraline, was approved by the FDA in 2006 and is made by several drug companies. A proposed defective drug class-action lawsuit against Zoloft was thrown out by a federal judge in California due to statute of limitations issues side effects from zoloft and other concerns. The California suit alleged the drug offers little more efficacy than a placebo, and argued that Pfizer purposely omitted from Zoloft labeling any studies that showed Zoloft to be ineffective. In dismissing the complaint, the judge did leave open the possibility that the suit could be revived after it's amended. Zoloft Warnings, zoloft carries a black-box warning because of an increased risk of suicide among people taking the drug. Studies have shown that antidepressants like Zoloft can increase suicidal thoughts and behaviors in children, adolescents, and younger adults who already have major depressive disorder or other psychiatric problems. However, in those older than 24, there was no increased risk and there was actually a reduction in risk among adults 65 and older. Your doctor will decide if the risks are acceptable and will monitor you closely. Your family and/or caregiver should be advised of the warning signs so that they can monitor you closely for possible problems.

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Side affects of zoloft


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